List of issues > Series «Biology. Ecology». 2014. Vol. 10
Heterogeneity of Population of A431 Human Skin Carcinoma Cells in Resistance Toward Anticancer Cytokine TRAIL
Author(s)
N. V. Dolgikh, A. V. Chekanov, V. S. Akatov
Abstract
Sensitivity of tumor cells to TRAIL-induced apoptosis is a key factor in the effectiveness of anticancer therapy based on the recombinant protein TRAIL. It is shown that stable TRAIL-sensitive and TRAIL-resistant sublines can be obtained from the population of the tumor cell line A431. Such sublines are a convenient tool for studying the mechanisms of sensitivity and resistance of tumor cells to TRAIL.
Keywords
anticancer protein TRAIL, tumor cell resistance, confluent culture
UDC
615.277.3