At present, the problem of environmental pollution caused by smoke from natural fires has acquired a regular character, and the problem itself has received scientific development. The long annual smoke from extensive areas dictates the need to study the long-term effects of the combustion products manifested in subsequent generations. The study is aimed at assessing the impact of forest landscape fires burning products in model experiment that are as close to natural conditions as possible on rats of different sex with the aim of establishing the character of transmission of epigenetic changes to the offspring. An experimental model has been developed for the effects of wildfire smoke exposure on small laboratory animals with characteristic of chemical composition of gases emitted. As fuel substrate used by the biomass, which is wood litter (moss, lichen, wood litter), twigs, pieces of bark and the top soil horizon (litter plants in various stages of degradation – from fresh to almost decomposed) completely burnable in real wildfire. In the exposition chamber, once every hour, samples air were analyzed for the content of CO, NO, formaldehyde, furfural and acetaldehyde. Concentrations of carbon monoxide in chamber during exposure was varied in the range of 13,5-49,7 mg/m³. Also revealed high concentration of acetaldehyde, furfural and formaldehyde. The reproductive function of rats exposed to smoke for 7 days was studied, as well as the functional state of CNS in adult offspring. Studies have shown that wildfire smoke exposure did not induce any significant changes in morphological picture of gonads and rat spermatogenesis, but their offspring showed a significant increase in deaths immediately after birth and mortality in the first week of life. Аfter wildfire smoke exposure showed a tendency to increase the level of DNA methylation in cells of the testes. At the same time, the transgenerational effect of exposure to combustion products was revealed, which manifested in persistent changes in behavior of offspring. Testing results of open field showed that adult offspring from exposed rats showed multidirectional changes in behavior indicators. Thus, the behavior of adult female from offspring was characterized by significant activation of locomotor activity and decrease of exploratory behavior, while males obtained from experimental animals, on the contrary, showed decrease in locomotor activity. In assessing the cognitive abilities of the offspring statistically significant change when compared with the control was not found. The significant effect of smoke smoke during forest fires on the health of the next generation justifies the need for in-depth studies. Particular interest is understanding the role of epigenetic paternal and maternal factors, as well as the combined effects of both parents in ensuring the survival and adaptive development of their offspring.

Vokina Vera Aleksandrovna, Candidate of Science (Biology), Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: vokina.vera@gmail.com 

Novikov Mikhail Aleksandrovich, Candidate of Science (Biology), Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: novik-imt@mail.ru 

Alekseenko Anton Nikolaevich, Candidate of Science (Chemistry), Senior Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: alexeenko85@mail.ru 

Sosedova Larisa Mikhailovna, Doctor of Science, Professor, Head of laboratory, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: sosedlar@mail.ru 

Kapustina Ekaterina Aleksandrovna, Candidate of Science (Medicine), Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail:kapustinkae@yandex.ru 

Bogomolova Elizaveta Sergeevna, Junior Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: liza.2995@mail.ru 

Elfimova Tatyana Aleksandrovna, Candidate of Science (Biology), Research Scientist, East-Siberian Institute of Medical and Ecological Research, 12A microdistrict, 3, Angarsk, 664003, Russian Federation, e-mail: borey1986@mail.ru

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