Action of a lipopolysaccharide (LPS) Francisella tularensis various subspecies, extracted by classic water-phenolic method and the twin-extraction on intensity of blood cells apoptosis of experimental animals in vivo is studying. Using modern methods of cellular biology LPS of tularemia agent, independently of a subspecies belonging, exert ambiguous influence on a level circulating apoptotic cells. The comparative analysis has showed that immune reactivity of macroorganism after inoculation of these preparations depends on a subspecies belonging as well as on virulence of F. tularensis.