The dynamics of lipid droplets volume in liver cells at different periods of experimental dyslipoproteinemia (to 90 days) were studied using Shinshilla rabbits by laser confocal microscopy. The analysis of liver preparations stained with DAPI (nuclei) and Nile red (lipid droplets) showed that as early as from the first weeks of experimental dyslipoproteinemia, the volume of lipid droplets significantly increases in liver cells. This makes the basis for the formation of structural and functional disturbances in the intracellular organelles that enhances dyslipoproteinemia. These results open the possibility of using confocal scanning microscopy for analysis of liver tissue samplings for early diagnostics of liver infiltrations with lipids.